Future Pharmaceutical Technologies Based on Dynamic Properties of Supermolecules; Transformable and Intelligent Pharmaceutical Materials

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  • Higashi Taishi
    Priority Organization for Innovation and Excellence, Kumamoto University Graduate School of Pharmaceutical Sciences, Kumamoto University

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  • 超分子の動的特性を駆使した未来型製剤設計―よく動き賢い製剤素材―
  • チョウブンシ ノ ドウテキ トクセイ オ クシ シタ ミライガタ セイザイ セッケイ : ヨク ウゴキ カシコイ セイザイ ソザイ

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<p>In recent years, various active pharmaceutical ingredients, such as natural compounds, small molecules, middle molecules, macromolecules, cells, machines, etc., have been developed aggressively. To design the formulations for these drugs, advanced pharmaceutical technologies and/or materials are needed. In this review article, we firstly propose the novel concept for future pharmaceutical sciences, supramolecular pharmaceutical sciences, which are the fusion of supramolecular chemistry and pharmaceutical sciences. Next, advanced pharmaceutical technologies and materials based on supramolecular pharmaceutical sciences, e.g. reversible PEGylation, polypseudorotaxane hydrogels, transformable supermolecules and polycatenanes, are introduced. These supramolecular pharmaceutical technologies and materials are dynamic and intelligent; therefore, we believe that supramolecular pharmaceutical sciences could be useful for development of future pharmaceutical technologies and materials.</p>

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