Arsenite exposure induces cellular senescence and increased SASP factors in hepatic stellate cells LX-2, and SASP factors remain highly expressed even after stopping the exposure

DOI
  • OKAMURA Kazuyuki
    National Institute for Environmental Studies, Center for Health and Environmental Risk Reseach
  • SUZUKI Takehiro
    National Institute for Environmental Studies, Center for Health and Environmental Risk Reseach
  • NOHARA Keiko
    National Institute for Environmental Studies, Center for Health and Environmental Risk Reseach

Bibliographic Information

Other Title
  • 無機ヒ素曝露によって誘導されたヒト肝星細胞LX-2の細胞老化ではSASP因子が増加し、曝露を中止しても高発現が維持される

Abstract

<p>Our previous study showed that 5 μM sodium arsenite exposure for 3 days in human hepatic stellate cell line LX-2 induced cellular senescence and expression of IL-8, one of the senescence-associated secretory phenotype (SASP). In this study, we examined whether the gene expression levels of other SASP factors besides IL-8 were increased. Our current study showed that 5 or 7.5 μM arsenite exposure for 6 days strongly induced gene expression levels of IL-1β, CXCL1, MMP1 and MMP3 in LX-2 cells. Furthermore, the expression levels of those genes were still maintained for 5 days after removing arsenite from medium.</p>

Journal

Details 詳細情報について

  • CRID
    1390289011244959744
  • NII Article ID
    130008073653
  • DOI
    10.14869/toxpt.48.1.0_o-12
  • Text Lang
    ja
  • Data Source
    • JaLC
    • CiNii Articles
  • Abstract License Flag
    Disallowed

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