Arsenite exposure induces cellular senescence and increased SASP factors in hepatic stellate cells LX-2, and SASP factors remain highly expressed even after stopping the exposure
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- OKAMURA Kazuyuki
- National Institute for Environmental Studies, Center for Health and Environmental Risk Reseach
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- SUZUKI Takehiro
- National Institute for Environmental Studies, Center for Health and Environmental Risk Reseach
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- NOHARA Keiko
- National Institute for Environmental Studies, Center for Health and Environmental Risk Reseach
Bibliographic Information
- Other Title
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- 無機ヒ素曝露によって誘導されたヒト肝星細胞LX-2の細胞老化ではSASP因子が増加し、曝露を中止しても高発現が維持される
Abstract
<p>Our previous study showed that 5 μM sodium arsenite exposure for 3 days in human hepatic stellate cell line LX-2 induced cellular senescence and expression of IL-8, one of the senescence-associated secretory phenotype (SASP). In this study, we examined whether the gene expression levels of other SASP factors besides IL-8 were increased. Our current study showed that 5 or 7.5 μM arsenite exposure for 6 days strongly induced gene expression levels of IL-1β, CXCL1, MMP1 and MMP3 in LX-2 cells. Furthermore, the expression levels of those genes were still maintained for 5 days after removing arsenite from medium.</p>
Journal
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- Annual Meeting of the Japanese Society of Toxicology
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Annual Meeting of the Japanese Society of Toxicology 48.1 (0), O-12-, 2021
The Japanese Society of Toxicology
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Details 詳細情報について
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- CRID
- 1390289011244959744
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- NII Article ID
- 130008073653
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- Text Lang
- ja
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- Data Source
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- JaLC
- CiNii Articles
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- Abstract License Flag
- Disallowed