Investigation of membrane permeability and metabolism of compounds in food using human iPS cell-derived small intestinal epithelial cells

DOI
  • KITAGUCHI Takashi
    Global Food Safety Institute, Nissin Foods Holdings Co., Ltd.
  • MIZOTA Taisei
    Global Food Safety Institute, Nissin Foods Holdings Co., Ltd.
  • ITO Mina
    Global Food Safety Institute, Nissin Foods Holdings Co., Ltd.
  • OHNO Katsutoshi
    Global Food Safety Institute, Nissin Foods Holdings Co., Ltd.
  • KOBAYASHI Kazuhiro
    Global Food Safety Institute, Nissin Foods Holdings Co., Ltd.
  • OGAWA Isamu
    Department of Clinical Pharmacy, Graduate School of Pharmaceutical Sciences, Nagoya City University
  • QIU Shimeng
    Department of Clinical Pharmacy, Graduate School of Pharmaceutical Sciences, Nagoya City University
  • IWAO Takahiro
    Department of Clinical Pharmacy, Graduate School of Pharmaceutical Sciences, Nagoya City University
  • HANIOKA Nobumitsu
    Department of Health Pharmacy, Yokohama University of Pharmacy
  • TANAKA Mitsuru
    Global Food Safety Institute, Nissin Foods Holdings Co., Ltd.
  • MATSUNAGA Tamihide
    Department of Clinical Pharmacy, Graduate School of Pharmaceutical Sciences, Nagoya City University

Bibliographic Information

Other Title
  • ヒトiPS細胞由来腸管上皮細胞を用いた食品中化合物の膜透過性および代謝予測性の検討

Abstract

<p>To investigate the membrane permeability and drug metabolic activities of human iPS cell-derived small intestinal epithelial cells, we compared these characteristics with Caco-2 cells or human primary enterocytes. Human iPS cell-derived intestinal epithelial cells showed a better correlation between intestinal absorption rates and membrane permeation rates than Caco-2 cells and showed close metabolic rates with human primary enterocytes for UGT substrates. Therefore, human iPS cell-derived intestinal epithelial cells might be a useful tool for predicting human intestinal absorption.</p>

Journal

Details 詳細情報について

  • CRID
    1390289011245072512
  • NII Article ID
    130008073761
  • DOI
    10.14869/toxpt.48.1.0_p-18
  • Text Lang
    ja
  • Data Source
    • JaLC
    • CiNii Articles
  • Abstract License Flag
    Disallowed

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