Investigation of membrane permeability and metabolism of compounds in food using human iPS cell-derived small intestinal epithelial cells
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- KITAGUCHI Takashi
- Global Food Safety Institute, Nissin Foods Holdings Co., Ltd.
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- MIZOTA Taisei
- Global Food Safety Institute, Nissin Foods Holdings Co., Ltd.
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- ITO Mina
- Global Food Safety Institute, Nissin Foods Holdings Co., Ltd.
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- OHNO Katsutoshi
- Global Food Safety Institute, Nissin Foods Holdings Co., Ltd.
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- KOBAYASHI Kazuhiro
- Global Food Safety Institute, Nissin Foods Holdings Co., Ltd.
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- OGAWA Isamu
- Department of Clinical Pharmacy, Graduate School of Pharmaceutical Sciences, Nagoya City University
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- QIU Shimeng
- Department of Clinical Pharmacy, Graduate School of Pharmaceutical Sciences, Nagoya City University
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- IWAO Takahiro
- Department of Clinical Pharmacy, Graduate School of Pharmaceutical Sciences, Nagoya City University
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- HANIOKA Nobumitsu
- Department of Health Pharmacy, Yokohama University of Pharmacy
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- TANAKA Mitsuru
- Global Food Safety Institute, Nissin Foods Holdings Co., Ltd.
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- MATSUNAGA Tamihide
- Department of Clinical Pharmacy, Graduate School of Pharmaceutical Sciences, Nagoya City University
Bibliographic Information
- Other Title
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- ヒトiPS細胞由来腸管上皮細胞を用いた食品中化合物の膜透過性および代謝予測性の検討
Abstract
<p>To investigate the membrane permeability and drug metabolic activities of human iPS cell-derived small intestinal epithelial cells, we compared these characteristics with Caco-2 cells or human primary enterocytes. Human iPS cell-derived intestinal epithelial cells showed a better correlation between intestinal absorption rates and membrane permeation rates than Caco-2 cells and showed close metabolic rates with human primary enterocytes for UGT substrates. Therefore, human iPS cell-derived intestinal epithelial cells might be a useful tool for predicting human intestinal absorption.</p>
Journal
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- Annual Meeting of the Japanese Society of Toxicology
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Annual Meeting of the Japanese Society of Toxicology 48.1 (0), P-18-, 2021
The Japanese Society of Toxicology
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Details 詳細情報について
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- CRID
- 1390289011245072512
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- NII Article ID
- 130008073761
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- Text Lang
- ja
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- Data Source
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- JaLC
- CiNii Articles
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- Abstract License Flag
- Disallowed