Issues in quality, efficacy and safety evaluation of mesenchymal stem cell processed products used for cell therapy

DOI
  • SAWADA Rumi
    Division of Cell-Based Therapeutic Products, National Institute of Health Sciences

Bibliographic Information

Other Title
  • 細胞治療に用いる間葉系幹細胞加工製品の品質、有効性及び安全性評価の課題

Abstract

<p>Owing to mesenchymal stem cells (MSCs) immunosuppressive, angiogenic, and tissue regeneration abilities and multilineage differentiation potential, MSCs are being used in cell therapy and regenerative medicine. On the other hand, there are many unclear points about the mode of action of treatment using MSCs. It is very difficult to analyze which function of MSCs the required efficacy depends on, and at present, there is no internationally established method for MSCs quality evaluation. Since there are many parts that do not apply to the concept of pharmaceuticals, it is necessary to establish an evaluation concept that is specific to stem cell processed products.</p>

Journal

Details 詳細情報について

  • CRID
    1390289011245096192
  • NII Article ID
    130008073911
  • DOI
    10.14869/toxpt.48.1.0_s24-4
  • Text Lang
    ja
  • Data Source
    • JaLC
    • CiNii Articles
  • Abstract License Flag
    Disallowed

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