Elucidation of the toxic mechanisms of polypeptide antibiotic polymyxin B

DOI
  • YAMADA Mayuka
    Lab. of Health Chem., Grad. Sch. of Pharmaceut. Sci., Tohoku Univ.
  • HIRATA Yusuke
    Lab. of Health Chem., Grad. Sch. of Pharmaceut. Sci., Tohoku Univ.
  • NOGUCHI Takuya
    Lab. of Health Chem., Grad. Sch. of Pharmaceut. Sci., Tohoku Univ.
  • MATSUZAWA Atsushi
    Lab. of Health Chem., Grad. Sch. of Pharmaceut. Sci., Tohoku Univ.

Bibliographic Information

Other Title
  • ポリペプチド抗菌薬ポリミキシンBの毒性発現機構の解明

Description

<p>Polymyxin B (PMB), a last-line antibiotic used against multidrug-resistant bacteria, causes undesirable cytotoxic side effects, including nephrotoxicity and neurotoxicity. However, its mechanisms remain unknown. In this study, we found that the E3 ubiquitin ligase MKRN1 strongly protects cells from the toxicity of PMB by suppressing PMB-induced ferroptosis, a newly discovered iron-dependent cell death. Thus, our study identified MKRN1 as a key determinant of the toxicity of PMB, which may provide a new strategy to overcome the cytotoxic side effects of PMB.</p>

Journal

Details 詳細情報について

  • CRID
    1390289011245626880
  • NII Article ID
    130008073615
  • DOI
    10.14869/toxpt.48.1.0_p-114s
  • Text Lang
    ja
  • Data Source
    • JaLC
    • CiNii Articles
  • Abstract License Flag
    Disallowed

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