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Time-Course evaluation of hepatomegaly in mice using micro-CT and the aspect interfering toxicological interpretation
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- KAWAMOTO Kensuke
- Environmental Health Science Laboratory, Sumitomo Chemical
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- YAMAGUCHI Kyohei
- Environmental Health Science Laboratory, Sumitomo Chemical
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- SHIMOTSUMA Yukako
- Environmental Health Science Laboratory, Sumitomo Chemical
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- MIYATA Kaori
- Environmental Health Science Laboratory, Sumitomo Chemical
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- ASANO Hiroyuki
- Environmental Health Science Laboratory, Sumitomo Chemical
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- SUKATA Tokuo
- Environmental Health Science Laboratory, Sumitomo Chemical
Bibliographic Information
- Other Title
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- micro-CTを用いたマウスにおける肝肥大の経時変化の評価ならびに撮影影響の検討
Description
<p>Micro-computed tomography (micro-CT) is an imaging modality that enable us to non-invasively obtain 3D images of organs in laboratory animals. By using micro-CT, internal organs can be monitored repeatedly, which leads to more precise evaluation and reduction in the number of animals used. In this study, we evaluated time-course of chemically-induced hepatomegaly in mice using micro-CT.</p><p>The liver volume calculated from CT images was highly correlated to the liver weight. Therefore, it was considered that CT imaging can be a useful tool for evaluating the time-course of hepatomegaly.</p>
Journal
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- Annual Meeting of the Japanese Society of Toxicology
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Annual Meeting of the Japanese Society of Toxicology 48.1 (0), P-42-, 2021
The Japanese Society of Toxicology
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Details 詳細情報について
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- CRID
- 1390289011246197504
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- NII Article ID
- 130008073846
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- Text Lang
- ja
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- Data Source
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- JaLC
- CiNii Articles
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- Abstract License Flag
- Disallowed