Molecular mechanism of tissue factor expression by arsenite in human aortic smooth muscle cells and macrophage-like THP-1 cells

DOI
  • NAKANO Tsuyoshi
    Department of Environmental Health, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences
  • ARAKI Yumi
    Department of Environmental Health, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences
  • TAKAHASHI Tsutomu
    Department of Environmental Health, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences
  • YAMAMOTO Chika
    Department of Environmental Health, Faculty of Pharmaceutical Sciences, Toho University
  • KAJI Toshiyuki
    Department of Environmental Health, Faculty of Pharmaceutical Sciences, Tokyo University of Science
  • FUJIWARA Yasuyuki
    Department of Environmental Health, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences

Bibliographic Information

Other Title
  • 血管平滑筋細胞及びマクロファージ様細胞における亜ヒ酸による組織因子の発現誘導機構

Abstract

<p>Arsenic is an environmental pollutant that causes atherosclerosis, although the pathogenic mechanisms are not fully elucidated. Tissue factor (TF) is the initiator of the coagulation and it has been shown to be involved in the development of atherosclerosis. In this study, we found that arsenite stimulates the expression of TF via activation of the Nrf2 pathway in both human aortic smooth muscle cells and macrophage-like human THP-1 cells. It is postulated that arsenite induces a procoagulant state of blood to progress atherosclerosis through induction of TF expression.</p>

Journal

Details 詳細情報について

  • CRID
    1390289011246213248
  • NII Article ID
    130008073788
  • DOI
    10.14869/toxpt.48.1.0_p-8
  • Text Lang
    ja
  • Data Source
    • JaLC
    • CiNii Articles
  • Abstract License Flag
    Disallowed

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