A Possible, Non-Invasive Method of Measuring Dynamic Lung Compliance in Patients with Interstitial Lung Disease Using Photoplethysmography

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  • Atsumi Kenichiro
    Department of Pulmonary Medicine and Oncology, Graduate School of Medicine, Nippon Medical School
  • Saito Yoshinobu
    Department of Pulmonary Medicine and Oncology, Graduate School of Medicine, Nippon Medical School
  • Tanaka Toru
    Department of Pulmonary Medicine and Oncology, Graduate School of Medicine, Nippon Medical School
  • Hayashi Hiroki
    Department of Pulmonary Medicine and Oncology, Graduate School of Medicine, Nippon Medical School
  • Kamio Koichiro
    Department of Pulmonary Medicine and Oncology, Graduate School of Medicine, Nippon Medical School
  • Seike Masahiro
    Department of Pulmonary Medicine and Oncology, Graduate School of Medicine, Nippon Medical School
  • Osaki Rie
    DENSO Corporation
  • Sakai Kazuhiro
    DENSO Corporation
  • Kurosawa Shinya
    DENSO Corporation
  • Gemma Akihiko
    Department of Pulmonary Medicine and Oncology, Graduate School of Medicine, Nippon Medical School
  • Azuma Arata
    Department of Pulmonary Medicine and Oncology, Graduate School of Medicine, Nippon Medical School
  • Kashiwada Takeru
    Department of Pulmonary Medicine and Oncology, Graduate School of Medicine, Nippon Medical School

書誌事項

公開日
2021-08-25
資源種別
journal article
DOI
  • 10.1272/jnms.jnms.2021_88-411
公開者
日本医科大学医学会

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説明

<p>Background: Measuring lung compliance is useful for evaluating progression of interstitial lung disease (ILD), because reduced lung compliance due to fibrosis progression is the main cause of decreased vital capacity. However, because insertion of a balloon into the esophagus is invasive, lung compliance is rarely measured. A recently developed method uses fingertip photoplethysmography to estimate intrathoracic pressure. This method non-invasively measures lung dynamic compliance (Cdyn) by simultaneously measuring tidal volume. We evaluated the efficacy of this method in assessing ILD. Methods: This single-center, cross-sectional, observational study evaluated the efficacy of this method in patients with ILD and healthy controls. The primary outcome was estimated Cdyn (eCdyn), as determined with this method. We also evaluated baseline characteristics that are potential confounding factors for eCdyn. Results: Median eCdyn was significantly lower in the ILD group (n = 14) than in the control group (n = 49) (0.122 vs. 0.183; P = 0.011). In univariate regression analysis, eCdyn was significantly correlated with height, weight, forced vital capacity, forced expiratory volume in 1 second, diffusing capacity for carbon monoxide, and usual interstitial pneumonia. In multivariate regression analysis, weight (β = 0.49, P = 0.011) and usual interstitial pneumonia (β = 0.52, P = 0.007) were significantly correlated with eCdyn. Conclusions: Using photoplethysmography, we noted a significant reduction in Cdyn in patients with ILD. This novel non-invasive method is a promising tool for evaluating fibrosis progression in ILD.</p>

収録刊行物

  • 日医大誌

    日医大誌 88 (4), 326-334, 2021-08-25

    日本医科大学医学会

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