Weaning from non-invasive respiratory support and the timing of CLD diagnosis in extremely preterm infants

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  • 早産児の非侵襲的呼吸管理離脱時期とCLD診断時期についての検討

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<p> Chronic lung disease（CLD）is an important prognostic factor that affects long-term outcomes in preterm infants. Although there exist different definitions of CLD, widely accepted diagnostic criteria is based on the dependence on non-invasive respiratory support（NRS）including supplemental oxygen at 28days after birth or at 36 weeks of post-conceptional age（PCA）.</p><p> However, some infants diagnosed as CLD show improved lung function and become free from any respiratory support before the term gestation.</p><p> This is explained by the fact that the current definition comprises a wide range of respiratory disorder such as functional prematurity of respiratory control system and/or anatomical prematurity of the lung that should resolve with age.</p><p> In this study, we aimed to define the right timing for diagnosing CLD by examining the timing of weaning from NRS in infants below 32 weeks of PMA who entered our NICU.</p><p> Results showed negative correlation between the gestational age at birth and the duration of NRS. That is, the lower the gestational age was, the longer the duration of NRS was. However, more than half infants who required NRS became free from NRS by 42 weeks of PCA.</p><p> In conclusion, the current diagnosis of CLD may include the respiratory disorder other than CLD.</p>

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