A case of solitary fibrous tumor arising in the meninge

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  • NAKANISHI Saori
    Department of Central Clinical Laboratory, Konan Medical Center, Konan Group, Public Interest Incorporated Foundation
  • KURODA Naoto
    Department of Pathology, Konan Medical Center, Konan Group, Public Interest Incorporated Foundation
  • TAKAI Toshiko
    Department of Central Clinical Laboratory, Konan Medical Center, Konan Group, Public Interest Incorporated Foundation
  • KOJIMA Mari
    Department of Central Clinical Laboratory, Konan Medical Center, Konan Group, Public Interest Incorporated Foundation
  • OONOGI Misato
    Department of Central Clinical Laboratory, Konan Medical Center, Konan Group, Public Interest Incorporated Foundation

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  • 髄膜に発生した孤立性線維性腫瘍の 1 例

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<p>Background : Solitary fibrous tumors (SFTs)/hemangiopericytomas (HPC) are mesenchymal neoplasms that rarely arise from the central nervous system. In this article, we report a case of SFT arising from the frontal region.</p><p>Case : A 45-year-old Japanese woman was transferred to our hospital with progressively worsening depression that was refractory to therapy. Imaging analysis revealed an irregularly-shaped tumor measuring 75mm in diameter on the frontal region. Meningioma was suspected and tumorectomy was performed. Frozen-section examination revealed patternless growth of short spindle-shaped cells with a high nuclear/cytoplasmic ratio with a large amount of collagen fibers in the storoma. Imprint cytology showed proliferation of short spindle-shaped cells and naked nuclei with collagen fibers. Whorl formation was absent and the findings were not typical of a meningioma. Immunohistochemical examination of the histological specimens showed positive staining of the tumor cells for CD34 and STAT6, and a final diagnosis of SFT/HPC was made.</p><p>Conclusion : Cytologists should consider the diagnosis of SFT/HPC when the no findings suggestive of a meningioma show short spindle-shaped neoplastic cells with naked nuclei.</p>

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