書誌事項
- タイトル別名
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- A case of oral hairy leukoplakia and EBV-positive mucocutaneous ulcer in a rheumatism patient
- コウコウモウジョウ ハクバンショウ ト EBV ヨウセイ ネンマク ヒフ カイヨウ オ ヘイハツ シタ リウマチ カンジャ ノ 1レイ
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<p>Oral hairy leukoplakia has been regarded as a lesion characteristic of human immunodeficiency virus (HIV) infection; however, many cases are reported in HIV-negative immunocompromised patients. A EBV-positive mucocutaneous ulcer was first reported by Dojcinov et al. in 2010 and was categorized as an EBV-associated lymphoproliferative disorder. The cause is EB virus reinfection associated with iatrogenic or age-related immunosuppression. We report a case in which OHL and EBVMCU coexisted. The case involved a 75-year-old woman who visited our department for the purpose of examining a white lesion on the right tongue margin. A smooth, thin, uniform white lesion with a shallow, flat, well-defined, painful ulcer was found on the right lingual margin. She had a medical history of rheumatoid arthritis, which was treated with oral methotrexate therapy. The white lesion was accompanied by an ulcer. We suspected leukoplakia, intractable ulcer, and methotrexate-related lymphoproliferative disorder (MTX-LPD), and performed a biopsy of her tongue. Results confirmed that the lesions were overlapped with the oral hairy leukoplakia and EBV-positive mucocutaneous ulcer. We considered iatrogenic immunosuppression as the cause, and methotrexate treatment was discontinued. The ulcer healed 4 weeks after methotrexate was discontinued, and the hairy leukoplakia thinned.</p>
収録刊行物
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- 日本口腔外科学会雑誌
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日本口腔外科学会雑誌 67 (7), 438-442, 2021-07-20
社団法人 日本口腔外科学会
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詳細情報 詳細情報について
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- CRID
- 1390289455274959872
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- NII論文ID
- 130008090737
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- NII書誌ID
- AN00189163
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- ISSN
- 21861579
- 00215163
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- NDL書誌ID
- 031640268
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
- NDL
- Crossref
- CiNii Articles
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- 使用不可