Effect of physician-prescribed nalmefene on alcohol intake reduction in patients with alcohol-related liver disease

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  • Horie Yoshinori
    Department of Gastroenterology, Shonan Keiiku Hospital
  • Taniki Nobuhito
    Division of Gastroenterology & Hepatology, Department of Internal Medicine, Keio University
  • Chu Po-sung
    Division of Gastroenterology & Hepatology, Department of Internal Medicine, Keio University
  • Nakamoto Nobuhiro
    Division of Gastroenterology & Hepatology, Department of Internal Medicine, Keio University
  • Kanai Takanori
    Division of Gastroenterology & Hepatology, Department of Internal Medicine, Keio University

Bibliographic Information

Other Title
  • アルコール関連肝疾患患者に対する内科医によるセリンクロ錠投与の飲酒量低減に対する効果
  • アルコール カンレン カン シッカン カンジャ ニ タイスル ナイカイ ニ ヨル セリンクロジョウ トウヨ ノ インシュリョウ テイゲン ニ タイスル コウカ

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<p>A brief intervention is often effective for patients with mild alcohol use disorder (AUD), but it is not effective for most patients with severe AUD or alcohol dependence to reduce alcohol intake. Nalmefene (Selincro®), an opioid receptor modulator, was approved in Japan in 2019. Nalmefene was administered to 18 outpatients with alcohol-related liver diseases. Five patients stopped coming to the hospital without notice, and two patients stopped taking medicine due to dizziness. Thus, 11 patients were noted to have reduced amount of alcohol intake at 24 weeks of using nalmefene. However, one of these patients was referred to a hospital specializing in alcohol dependence thereafter. Thus, the use of nalmefene provides a new concept for AUD treatment (i. e., alcohol intake reduction). However, some adverse events are noted, such as nausea and dizziness. Therefore, physicians with more experience with AUD treatment should use the drug.</p>

Journal

  • Kanzo

    Kanzo 62 (10), 620-629, 2021-10-01

    The Japan Society of Hepatology

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