Endobronchial Lesions from Disseminated <i>Mycobacterium avium</i> Infection in a Patient with Anti-interferon-gamma Autoantibodies

  • Mochizuka Yasutaka
    Department of Pulmonary Medicine, Seirei Hamamatsu General Hospital, Japan
  • Kono Masato
    Department of Pulmonary Medicine, Seirei Hamamatsu General Hospital, Japan
  • Hirama Ryutaro
    Department of Pulmonary Medicine, Seirei Hamamatsu General Hospital, Japan
  • Oshima Yuiko
    Department of Pulmonary Medicine, Seirei Hamamatsu General Hospital, Japan
  • Takeda Kenichiro
    Department of Pulmonary Medicine, Seirei Hamamatsu General Hospital, Japan
  • Tsutsumi Akari
    Department of Pulmonary Medicine, Seirei Hamamatsu General Hospital, Japan
  • Miwa Hideki
    Department of Pulmonary Medicine, Seirei Hamamatsu General Hospital, Japan
  • Miki Yoshihiro
    Department of Pulmonary Medicine, Seirei Hamamatsu General Hospital, Japan
  • Hashimoto Dai
    Department of Pulmonary Medicine, Seirei Hamamatsu General Hospital, Japan
  • Kimura Toshiki
    Department of Respiratory Medicine, Faculty of Life Sciences, Kumamoto University, Japan
  • Sakagami Takuro
    Department of Respiratory Medicine, Faculty of Life Sciences, Kumamoto University, Japan
  • Nakamura Hidenori
    Department of Pulmonary Medicine, Seirei Hamamatsu General Hospital, Japan

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<p>A 78-year-old man was admitted to our hospital with a fever and left chest pain. Computed tomography showed multiple lung nodules, narrowing of the right bronchus intermedius with mediastinal lymphadenopathy, and an osteolytic lesion. Bronchoscopic findings showed rapid progression of multiple polypoid lesions and the bronchial stenosis. A biopsy of the endobronchial lesions revealed non-necrotizing granulomatous inflammation, and a tissue culture identified Mycobacterium avium. An anti-human immunodeficiency virus antibody was negative. Finally, anti-interferon-gamma (IFN-γ) autoantibodies were detected, and the patient was diagnosed with disseminated nontuberculous mycobacterium infection with anti-IFN-γ autoantibodies. Antimycobacterial therapy was effective, and radiographic findings, including the endobronchial lesions, were resolved. </p>

収録刊行物

  • Internal Medicine

    Internal Medicine 60 (20), 3267-3272, 2021-10-15

    一般社団法人 日本内科学会

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