書誌事項
- タイトル別名
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- A case of lung adenocarcinoma with mandibular metastasis successfully controlled with alectinib
- アレクチニブ トウヨ ニ ヨリ コントロール サレタ ハイ センガン カガク コツ テンイ ノ 1レイ
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<p>Metastatic malignancies transferring to the oral and maxillofacial region from other organs account for about 1% of oral malignancies, and the prognosis is poor. Herein we report a case of lung adenocarcinoma discovered as a first indication of mandibular metastasis, which has been successfully controlled with alectinib, an Anaplastic Lymphoma Kinase (ALK) inhibitor. The patient was a 68-year-old women who visited our hospital complaining of swelling of the left mandibular gingiva and tooth mobility. Contrast-enhanced CT showed an ill-defined bone destruction in the left lower molar region of the mandible, and a biopsy was performed on the suspicion of a malignant tumor on the left mandible. The histopathological diagnosis was adenocarcinoma. An FDG-PET / CT examination showed accumulation of FDG in the S10 region of the right lung, and a medical oncologist clinically diagnosed mandibular metastasis of lung adenocarcinoma. Since immunohistochemical examination revealed positive for the ALK fusion gene and PD-L1 protein, the ALK inhibitor alectinib was administrated. At six months after the start of administration, the lesions of the primary and mandibular metastases disappeared from the image, and as of 3 years and 6 months after the start of administration, alectinib has been continued without major adverse events.</p>
収録刊行物
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- 日本口腔外科学会雑誌
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日本口腔外科学会雑誌 67 (8), 484-489, 2021-08-20
社団法人 日本口腔外科学会
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詳細情報 詳細情報について
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- CRID
- 1390289774666945920
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- NII論文ID
- 130008105926
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- NII書誌ID
- AN00189163
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- ISSN
- 21861579
- 00215163
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- NDL書誌ID
- 031681730
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
- NDL
- Crossref
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可