Development of functional foods effective for bedridden and weightlessness-induced muscle atrophy

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  • Fukushima Taku
    Department of Nutritional Physiology, Institute of Medical Nutrition, Tokushima University Graduate School
  • Sakakibara Iori
    Department of Nutritional Physiology, Institute of Medical Nutrition, Tokushima University Graduate School
  • Nikawa Takeshi
    Department of Nutritional Physiology, Institute of Medical Nutrition, Tokushima University Graduate School Biomedical Sciences Institute of Space Nutrition, Tokushima University Graduate School

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  • 寝たきりや無重力による筋萎縮に有効な機能性食材の開発
  • 第62回大会特別講演 寝たきりや無重力による筋萎縮に有効な機能性食材の開発
  • ダイ62カイ タイカイ トクベツ コウエン ネタ キリ ヤ ムジュウリョク ニ ヨル キン イシュク ニ ユウコウ ナ キノウセイショクザイ ノ カイハツ

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Abstract

<p>　As Japan enters a super-aging society, there is an urgent need to extend the healthy life span of the elderly. In order to extend the healthy life span, it is essential to prevent physical declines caused by aging. One of the age-related changes is muscle atrophy (sarcopenia). Previous studies have shown that age-related muscle atrophy is caused by a mechanism similar to that of bedridden and weightlessness-induced muscle atrophy. Weightlessness induces oxidative stress and increased expression of the ubiquitin ligase Cbl-b, which induces ubiquitination and degradation of IRS-1 and inhibits IGF-1 signaling, resulting in muscle atrophy. ROS accumulation can be suppressed by antioxidant polyphenols, and Cbl-b can be inhibited by the Cblin peptide (Cbl-b inhibitor) and the anti-ubiquitinating soy protein glycinin. Furthermore, recent studies have shown that morin, a natural flavonoid with potent antioxidant properties, inhibits muscle atrophy induced by dexamethasone (Dex). We propose the usefulness of these functional ingredients and the importance of nutrition for muscle atrophy and aim to devise a nutritional treatment.</p>

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