Quantification of Cathinone Analogues without Reference Standard Using ¹H Quantitative NMR

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  • ZHAO Yuxin
    School of Pharmacy, China Pharmaceutical University China Pharmaceutical University Joint Laboratory on Key Technologies of Narcotics Control, China National Narcotics Control Commission
  • WU Bo
    School of Pharmacy, China Pharmaceutical University The Narcotic Control Division, Nanjing Municipal Public Security Bureau
  • HUA Zhendong
    China Pharmaceutical University Joint Laboratory on Key Technologies of Narcotics Control, China National Narcotics Control Commission Key Laboratory of Drug Monitoring and Control, Drug Intelligence and Forensic Center, Ministry of Public Security
  • XU Peng
    China Pharmaceutical University Joint Laboratory on Key Technologies of Narcotics Control, China National Narcotics Control Commission Key Laboratory of Drug Monitoring and Control, Drug Intelligence and Forensic Center, Ministry of Public Security
  • XU Hui
    School of Pharmacy, China Pharmaceutical University China Pharmaceutical University Joint Laboratory on Key Technologies of Narcotics Control, China National Narcotics Control Commission
  • SHEN Wenbin
    Center for Instrumental Analysis, China Pharmaceutical University
  • DI Bin
    School of Pharmacy, China Pharmaceutical University China Pharmaceutical University Joint Laboratory on Key Technologies of Narcotics Control, China National Narcotics Control Commission
  • WANG Youmei
    China Pharmaceutical University Joint Laboratory on Key Technologies of Narcotics Control, China National Narcotics Control Commission Key Laboratory of Drug Monitoring and Control, Drug Intelligence and Forensic Center, Ministry of Public Security
  • SU Mengxiang
    School of Pharmacy, China Pharmaceutical University China Pharmaceutical University Joint Laboratory on Key Technologies of Narcotics Control, China National Narcotics Control Commission

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  • Quantification of Cathinone Analogues without Reference Standard Using <sup>1</sup>H Quantitative NMR

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<p>Synthetic cathinones are a type of new psychoactive substances (NPS) that have been seriously abused. Owing to the rapid variation in their structures, the absence of reference standards poses a challenge in quantitative investigations. In this study, a 1H quantitative nuclear magnetic resonance (1H qNMR) method was established using maleic acid as the internal standard and the shared signal (i.e., the methylidyne hydrogen) on the parent synthetic cathinones structure as the quantitative peak. Taking 3-methoxy-2-(methylamino)-1-(4-methylphenyl)propan-1-one (mexedrone) as an example, this study optimized the acquisition parameters and conducted method validation, including an evaluation of the specificity, linearity, accuracy, precision, and robustness. Using this 1H qNMR method, the contents of mexedrone and its analogues, including 1-(3-chlorophenyl)-2-(ethylamino)-propan-1-one (3-CEC), 4-chloro-α-pyrroli-dinopropiophenone (4-Cl-α-PVP), 1-(3,4-methylenedioxy-phenyl)-2-propylamino-propan-1-one (propylone), and methcathinone, were obtained. The obtained results showed that the method was accurate, rapid, versatile, and can be used to address the qualitative and quantitative issues related to similar substances.</p>

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  • Analytical Sciences

    Analytical Sciences 37 (11), 1577-1582, 2021-11-10

    社団法人 日本分析化学会

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