mRNA technology: mRNAs that accelerate a turn-over of the translation reaction cycle

DOI
  • Abe Naoko
    Chemistry Department, Graduate School of Science, Nagoya University
  • Abe Hiroshi
    Chemistry Department, Graduate School of Science, Nagoya University

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Other Title
  • mRNA技術：翻訳反応サイクルを加速するmRNA

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Abstract

Currently, mRNA is used for vaccine therapy against COVID-19. However, the mRNA vaccine is urgently approved under a pandemic, there are still issues to be solved in terms of delivery method, quality/ purity, stability/ effect sustainability, protein synthesis efficiency, and so on. Research and development of mRNA drugs have been mainly focused on the development of delivery methods, and only biological methods are used for mRNA production. It is important to develop molecular design methods and synthetic methods hereafter. We focus on the translation mechanism of mRNA and propose a molecular design that can promote the translation by accelerate its rate-determining step. Based on experimental data, we will explain here the strategy for the molecule design that can improve the translation efficiency and stability of mRNA.

Journal

  • MEDCHEM NEWS

    MEDCHEM NEWS 31 (4), 194-199, 2021

    The Pharmaceutical Society of Japan

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