Retention of Anti-pertussis Toxin Antibodies after Whooping Cough-containing Vaccination in Healthcare Workers and the Appropriate Timing for Booster Inoculation

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  • FUSHIMI Kana
    Infection Control Committee, Shizuoka City Shimizu Hospital
  • IKEGAYA Kazuko
    Infection Control Committee, Shizuoka City Shimizu Hospital Department of Clinical Laboratory, Shizuoka City Shimizu Hospital
  • TSUCHIYA Ken
    Infection Control Committee, Shizuoka City Shimizu Hospital Department of Clinical Laboratory, Shizuoka City Shimizu Hospital
  • SAITO Atsuko
    Infection Control Committee, Shizuoka City Shimizu Hospital
  • SARATANI Kazuma
    Infection Control Committee, Shizuoka City Shimizu Hospital Department of Pharmacy, Shizuoka City Shimizu Hospital
  • TOKUHAMA Junichi
    Infection Control Committee, Shizuoka City Shimizu Hospital Department of Pharmacy, Shizuoka City Shimizu Hospital
  • HARADA Seiji
    Infection Control Committee, Shizuoka City Shimizu Hospital Department of Pharmacy, Shizuoka City Shimizu Hospital
  • ASHIZAWA Hiroki
    Infection Control Committee, Shizuoka City Shimizu Hospital Department of Respiratory Medicine, Shizuoka City Shimizu Hospital
  • MASUDA Masafumi
    Infection Control Committee, Shizuoka City Shimizu Hospital Department of Respiratory Medicine, Shizuoka City Shimizu Hospital

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Other Title
  • 医療従事者におけるDTaP接種後の経時的百日咳抗体保有状況の評価と追加接種時期の検討

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<p>At our hospital, we performed DPT vaccination for healthcare workers and measured the titer of anti-pertussis toxin antibodies before and after vaccination and in the long-term post-vaccination course. These results were used to determine the appropriate timing for booster inoculation based on the time at which the antibody titer decreases.</p><p>The prevalence of anti-pertussis toxin antibodies in the healthcare workers was 64.4% (67/104 people) before DPT vaccination. The antibody titer significantly increased 4 weeks after DPT vaccination and then decreased over the years after vaccination. After 6 years, 100% (7/7 people) of the healthcare workers still had antibodies, but this rate decreased to 68.5% (24/35 people) at 7 years after vaccination. Therefore, we concluded that monitoring of the antibody titer and booster inoculation as needed are required for healthcare workers at 7 years after DPT vaccination at our hospital. However, the timing of the decrease of the antibody titer and the booster inoculation may differ depending on the level of pertussis toxin and the medical and economic situations in different countries and regions. Therefore, the timing of the booster inoculation should also be based on the local disease level in Japan and overseas.</p>

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