Evaluation of oral cyanocobalamin-loaded nanoparticles for intestinal absorption

Sugiyama Ikumi, Soma Yukako, Sadzuka Yasuyuki

doi:10.24750/iwateishi.73.4_141

We developed a vitamin B12 (VB12)-containing formulation for oral administration that resulted in the absorption of VB12 without gastric intrinsic factor (IF). Patients who cannot secrete IF after the removal of their stomachs are at an increased risk of megaloblastic anemia (MA) and thus require continuous, invasive treatment with VB12 administration to improve absorption. A simple and noninvasive method for MA treatment or prevention is desired. We believe that pharmaceutical effort through a drug delivery system can resolve the absorption efficiency of VB12, which is administered orally when there is no IF in the stomach. Liposomes prepared with the thin film method contain charged lipids and were modified with polyethylene glycol on their membrane. The liposomes contained sufficient cyanocobalamin (Cyc) for VB12 therapy. Administering Cyc-loaded liposome (Cyc-L) resulted in a higher Cyc concentration of serum than that of the Cyc solution. Cyc loaded into liposomes is taken up more easily than in solution state without remaining in the ileum even if IF is present. These results indicate that Cyc-L is a useful formulation because it can elevate the concentration of serum Cyc via oral administration. Thus, Cyc-L may improve the quality of life of many patients who have had their stomachs removed.

Evaluation of oral cyanocobalamin-loaded nanoparticles for intestinal absorption

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