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Acquired Factor V Inhibitor Complicated with Immune Thrombocytopenia
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- Mima Fuka
- Department of Hematology, Hyogo Prefectural Nishinomiya Hospital, Japan
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- Minami Ryota
- Department of Hematology, Hyogo Prefectural Nishinomiya Hospital, Japan
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- Asako Mizuki
- Department of Hematology, Hyogo Prefectural Nishinomiya Hospital, Japan
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- Matsunaga Hitomi
- Department of Hematology, Hyogo Prefectural Nishinomiya Hospital, Japan
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- Fujita Yuri
- Department of Clinical Laboratory, Hyogo Prefectural Nishinomiya Hospital, Japan
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- Takimoto Yoshimi
- Department of Clinical Laboratory, Hyogo Prefectural Nishinomiya Hospital, Japan
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- Senda Sonoko
- Department of Clinical Laboratory, Hyogo Prefectural Nishinomiya Hospital, Japan
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- Nakahara Wataru
- Department of Hematology, Hyogo Prefectural Nishinomiya Hospital, Japan
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- Ikeda Mako
- Department of Hematology, Hyogo Prefectural Nishinomiya Hospital, Japan
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- Ueda Shuji
- Department of Hematology, Hyogo Prefectural Nishinomiya Hospital, Japan
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Description
<p>We herein report a patient with a high bleeding tendency as a result of acquired factor V inhibitor and immune thrombocytopenia (ITP). The administration of prednisolone increased the platelet count, but a fatal bleeding event occurred before platelet levels had sufficiently increased. Factor V is stored in not only plasma but also platelets, and platelet-derived factor V might play a local hemostatic role. Bleeding tendency may be high in rare cases where factor V inhibitor is complicated with severe thrombocytopenia. In such patients, physicians should consider aggressive hemostatic therapy, including plasma exchange, in addition to immunosuppressive therapy. </p>
Journal
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- Internal Medicine
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Internal Medicine 61 (1), 91-95, 2022-01-01
The Japanese Society of Internal Medicine
