Brain-Gut Interaction and Gut Microbiota in Irritable Bowel Syndrome

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  • Sato Ken
    Health Service Center, Hirosaki University

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  • 過敏性腸症候群における脳腸相関と腸内細菌叢
  • カビンセイ チョウ ショウコウグン ニ オケル ノウ チョウ ソウカン ト チョウ ナイ サイキンソウ

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Abstract

<p>Gut microbiota has been shown to influence various diseases, and it has become clear that it is also associated with the pathophysiology of irritable bowel syndrome (IBS). Gut microbiota dysbiosis increases mucosal permeability and sensitizes visceral nociception, while sensory irritation occurs in the central nervous system through the spinal nerve. Abnormal brain processing causes IBS symptoms. It is important to understand the concept of the brain-gut-microbiota axis to understand the pathophysiology of IBS.</p><p>Probiotics, antibiotics, and fecal microbiota transplantation (FMT) are gradually performed to treat the altered gut microbiota of IBS, but antibiotics and FMT are not covered by insurance in Japan. Further investigations are expected.</p>

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