Medaka as a model organism for research in experimental biology

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Abstract

The medaka, Oryzias latipes, has been widely used as an experimental animal in Japan, because of its relatively short life cycle (2 to 3 months), high fecundity (laying over 10 eggs daily) and small size (saving space for large-scale breeding). In this review, we will describe the development of the medaka as an experimental animal based on its characteristics, availability of several experimental methodologies, mutant and inbred strains, and availability of other species of the genus Oryzias and related genera. We also describe advantages and disadvantages of the medaka compared with other small freshwater fish such as zebrafish, platyfish and swordtail.

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