A Case of Paroxysmal Atrial Fibrillation Improved after the Administration of Proton Pump Inhibitor for Associated Reflux Esophagitis

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  • Nakamura Hirofumi
    Department of Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Sciences
  • Nakaji Gen
    Department of Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Sciences
  • Shimazu Hideki
    Department of Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Sciences
  • Yasuda Shioto
    Department of Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Sciences
  • Odashiro Keita
    Department of Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Sciences
  • Maruyama Toru
    Institute of Health Science, Kyushu University
  • Kaji Yoshikazu
    Department of Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Sciences
  • Chishaki Akiko
    Department of Health Sciences, School of Medicine, Kyushu University

Bibliographic Information

Other Title
  • 逆流性食道炎に対して投与したプロトンポンプ阻害剤が奏功した発作性心房細動の一例
  • Case report: A case of paroxysmal atrial fibrillation improved after the administration of proton pump inhibitor for associated reflux esophagitis

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Abstract

A 64-year-old man had demonstrated palpitations caused by paroxysmal atrial fibrillation (AF) documented by ambulatory electrocardiographic monitoring. Effectiveness of antiarrhythmic agent (disopyramide: 300 mg/day) was limited. Based on the gastrointestinal endoscopic findings, proton pump inhibitor (PPI : rabeprazole, 10mg/day)was administered to eliminate heart burn due to reflux esophagitis. Symptoms of paroxysmal AF and reflux esophagitis were confusing due to the anatomical proximity of the diseased organs and concomitant occurrence in the evening and when in a supine position. After the additional PPI therapy, not only was reflux esophagitis improved subjectively and endoscopically but also paroxysms of AF markedly reduced. Because esophagus is attached to left atrial posterior wall and the role of inflammatory process on the development of AF is highlighted,amelioration of reflux esophagitis by PPI may have been followed by the remarkable reduction of paroxysms of AF.

Journal

  • 福岡醫學雜誌

    福岡醫學雜誌 98 (6), 270-276, 2007-06-25

    Fukuoka Medical Association

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