Estimation of Indication for Living Donor Liver Transplantation in Patients with HCV and/or HBV Infection

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  • Inoue Sawako
    Department of Medicine and Bioregulatory Science, Kyushu University
  • Morizono Shusuke
    Department of Medicine and Bioregulatory Science, Kyushu University
  • Yamashita Shinsaku
    Department of Medicine and Bioregulatory Science, Kyushu University
  • Horikawa Yuki
    Department of Medicine and Bioregulatory Science, Kyushu University
  • Kohjima Motoyuki
    Department of Medicine and Bioregulatory Science, Kyushu University
  • Miyagi Yuzuru
    Department of Medicine and Bioregulatory Science, Kyushu University
  • Yoshimoto Tsuyosi
    Department of Medicine and Bioregulatory Science, Kyushu University
  • Kotoh Kazuhiro
    Department of Medicine and Bioregulatory Science, Kyushu University
  • Enjoji Munechika
    Department of Medicine and Bioregulatory Science, Kyushu University
  • Takayanagi Ryoichi
    Department of Medicine and Bioregulatory Science, Kyushu University
  • Soejima Yuji
    Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University
  • Taketomi Akinobu
    Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University
  • Yoshizumi Tomoharu
    Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University
  • Maehara Yoshihiko
    Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University
  • Nakamuta Makoto
    Department of Gastroenterology, Kyushu Medical Center, National Hospital Organization

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Other Title
  • ウイルス肝炎，特に肝細胞癌合併症例に対する生体肝移植適応評価の現況
  • ウイルス カンエン トクニ カン サイボウ ガン ガッペイ ショウレイ ニ タイスル セイタイ カン イショク テキオウ ヒョウカ ノ ゲンキョウ

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Abstract

We evaluated 78 patients with chronic viral hepatitis for liver transplantation. 51 patients met our original criteria for liver transplantation,and 35 patients of them suffered from hepatocellular carcinoma (HCC). Patients with HCC were significantly older and showed higher prothrombin activity than those without HCC. Eighteen of 35 patients with HCC did not meet the Milan criteria, and they showed lower levels of total bilirubin, Child-Pugh score, and MELD score than those who met the criteria. Theses results indicate that acceptability for transplantation should be evaluated soon after the patients have become candidates for liver transplantation. In Japan, decompensated liver cirrhosis is a necessary condition for the application of public health insurance against liver transplantation and,in cases with HCC,it is necessary to meet the Milan criteria.Application to liver transplantation should also be considered based on HCC stage such as the UNOS scoring system.

Journal

  • 福岡醫學雜誌

    福岡醫學雜誌 98 (7), 295-300, 2007-07-25

    Fukuoka Medical Association

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