書誌事項
- タイトル別名
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- A Delayed Type Hypersensitivity (DTH) Skin Reaction to Hepatitis B Surface Antigen (HBsAg) and Intradermal Hepatitis B Vaccination
- Delayed Type Hypersensitivity DTH Skin Reaction to Hepatitis B Surface Antigen HBsAg and Intradermal Hepatitis B Vaccination
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説明
The significance of a delayed type hypersensitivity skin reaction to hepatitis B surface antigen (HBsAg) (HBs-DTH) in type B viral hepatitis (VHB) and in intradermal hepatitis B (HB) vaccination is reviewed. HBs-DTH could be developed by the intradermal injection of HB vaccine in anti-HBs positive people and also in persons immunized with HB vaccine. Thus, HBs-DTH could serve as a useful marker for the acquisition of an active Thl type immunoreactivity to HBsAg. HBs-DTH was absent in patients with chronic VHB. In contrast, HBs-DTH developed early in the convalescent phase of the acute VHB, whereas the production of anti-HBs was significantly delayed, thus suggesting that HBs-DTH may be involved in the recovery mechanisms of acute VHB. Intradermal HB vaccination is useful not only in lowering the cost, but also in the rapid development of anti-HBs, reversing non-responsiveness, improving postexposure prophylaxis and in immunizing immunosuppressed people. A similar vaccination strategy should prove to be useful in prevention and control of not only other infectious diseases but also malignant neoplasms.
収録刊行物
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- 福岡醫學雜誌
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福岡醫學雜誌 95 (12), 305-313, 2004-12-25
福岡医学会
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詳細情報 詳細情報について
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- CRID
- 1390290699740406784
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- NII論文ID
- 120002834530
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- NII書誌ID
- AN00215478
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- DOI
- 10.15017/19250
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- HANDLE
- 2324/19250
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- NDL書誌ID
- 7284256
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- ISSN
- 0016254X
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- PubMed
- 15732372
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- IRDB
- NDL
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用可