Serum Levels of IL-21 and TGF-β in the Yusho Patients
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- Kuwatsuka Yutaka
- Department of Dermatology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan
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- Koike Yuta
- Research and Clinical Center for Yusho and Dioxin, Kyushu University Hospital, Fukuoka, Japan.
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- Shimizu Kazuhiro
- Department of Dermatology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan
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- Utani Atsushi
- Department of Dermatology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan
Bibliographic Information
- Other Title
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- 油症認定患者におけるIL-21, TGF-βの検討
- ユショウ ニンテイ カンジャ ニ オケル IL-21,TGF-v ノ ケントウ
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Abstract
Aryl hydrocarbon receptor (AhR), recognized as a dioxin receptor, is expressed on the surface of helper T (Th) 17 cells. As PCBs and PCDFs are still detected in the sera of the Yusho patients, we hypothesized dysregulation of Th17 cells in the Yusho patients. In the present study, we measured IL-21 and TGF-β in the Yusho patients which induce differentiation from Th0 to Th17 cells. Serum levels of IL-21 were lower than those of controls (p < 0.05). Meanwhile, serum levels of TGF- β were decreased relative to controls, but not significant. These results may imply differentiation from Th0 cells to Th17 cells is not induced in the Yusho patients.
Journal
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- 福岡醫學雜誌
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福岡醫學雜誌 104 (4), 88-90, 2013-04-25
Fukuoka Medical Association
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Details 詳細情報について
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- CRID
- 1390290699740728576
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- NII Article ID
- 120005303393
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- NII Book ID
- AN00215478
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- DOI
- 10.15017/26696
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- HANDLE
- 2324/26696
- 10069/34015
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- NDL BIB ID
- 024893241
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- ISSN
- 0016254X
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- PubMed
- 23858784
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- Text Lang
- ja
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- Data Source
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- JaLC
- IRDB
- NDL
- PubMed
- CiNii Articles
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- Abstract License Flag
- Allowed