Relationships between Half-Lives of Dioxins and SNPs in AhR among Yusho Patients

DOI HANDLE Web Site PubMed Open Access
  • Matsumoto Shinya
    Department of Public Health, Health Management and Policy,Nara Medical University School of Medicine
  • Akahane Manabu
    Department of Public Health, Health Management and Policy, Nara Medical University School of Medicine
  • Kanagawa Yoshiyuki
    Department of Public Health, Health Management and Policy, Nara Medical University School of Medicine
  • Kajiwara Jumboku
    Fukuoka Institute of Health and Environmental Sciences
  • Tsukimori Kiyomi
    Fukuoka Childrenʼs Hospital
  • Wake Norio
    Research Center for Environment and Developmental Medical Sciences
  • Mitoma Chikage
    Research and Clinical Center for Yusho and Dioxin, Kyushu University Hospital
  • Uchi Hiroshi
    Department of Dermatology, Graduate School of Medical Science, Kyushu University
  • Furue Masutaka
    Department of Dermatology, Graduate School of Medical Science, Kyushu University | Research and Clinical Center for Yusho and Dioxin, Kyushu University Hospital
  • Imamura Tomoaki
    Department of Public Health, Health Management and Policy, Nara Medical University School of Medicine

Bibliographic Information

Other Title
  • カネミ油症患者のダイオキシン類の半減期と芳香族炭化水素受容体(AhR)のSNPの関係
  • カネミユショウ カンジャ ノ ダイオキシンルイ ノ ハンゲンキ ト ホウコウゾク タンカスイソ ジュヨウタイ(AhR)ノ SNP ノ カンケイ

Search this article

Abstract

Half-lives of blood levels of 2,3,4,7,8-Pentachlorodibenzofuran (PeCDF) are varied in Yusho patients. The objective was to evaluate a relationship between half-lives of PeCDF levels and types of SNP rs10249788 of aryl hydrocarbon receptor (AHR) gene in 93 Yusho patients. Based on physical symptoms, age, sex, body mass index and other factors, we set up suitable calculation formulas to fit the actual PeCDF levels thorough rates of change in PeCDF.We found that patients with C/T SNP had longer half lives than patients with C/C and T/T SNPs. Patients with T/T SNP are known to express higher amount of AHR mRNAs. However, detailed analysis could not be carried out in T/T group due to a limited number of patients (n=11). Further research is warranted to determine the cause of the longer half-lives in C/T patients.

Journal

  • 福岡醫學雜誌

    福岡醫學雜誌 106 (5), 139-143, 2015-05-25

    Fukuoka Medical Association

Keywords

Details 詳細情報について

Report a problem

Back to top