Development of New Treatment in Pediatric Intractable Disease using Regenerative Medicine : Focusing on Stem Cells from Human Exfoliated Deciduous Teeth

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  • TAGUCHI Tomoaki
    Fukuoka College of Health Sciences Kyushu University : Professor Emeritus
  • MINAMI Reira
    Department of Dental Hygiene, Fukuoka College of Health Sciences
  • KAWASHIRI Nozomi
    Department of Dental Hygiene, Fukuoka College of Health Sciences
  • MORI Sayaka
    Department of Dental Hygiene, Fukuoka College of Health Sciences
  • YOSHIMARU Koichiro
    Department of Pediatric Surgery, Graduate School of Medical Sciences, Kyushu University
  • TAKAHASHI Yoshiaki
    Department of Pediatric Surgery, Graduate School of Medical Sciences, Kyushu University
  • YAMAZA Takayosi
    Department of Molecular Cell Biology and Oral Anatomy, Graduate School of Dental Sciences, Kyushu University
  • SUITA Sachiyo
    Fukuoka Gakuen Kyushu University, Professor Emeritus

Bibliographic Information

Other Title
  • 小児難治性疾患に対する再生医療を用いた新規治療の開発 : 主に脱落乳歯幹細胞に着目して
  • ショウニ ナンチセイ シッカン ニ タイスル サイセイ イリョウ オ モチイタ シンキ チリョウ ノ カイハツ : オモニ ダツラク ニュウシ カンサイボウ ニ チャクモク シテ

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Abstract

Regenerative medicine using stem cell can provide new treatment modalities for intractable diseases. Stem cells from human exfoliated deciduous teeth (SHED) share some characteristics of mesenchymal stem cells (MSCs), and exhibit self-renewal, multipotency into a variety of mature cells. Recent studies have conducted to evaluate the immunomodulatory effects of SHED, which are considered a feasible cell source for tissue engineering and regenerative medicine. In comparison with other stem cells, SHED have the distinct advantages of minimal risk of oncogenesis and less ethical controversy, and a readily accessible source, easy and minimally invasive collection. SHED have also high stem cell potential such as cell proliferation, multipotency, and immunosuppressive ability even after cryopreservation. Even in adult, we may use wisdom teeth or buried teeth for harvesting dental pulp stem cell. Currently, some companies have been creating a SHED bank for allogenic cell therapy in future. They are also collaborating us for clinical study using autologous SHED. We have been trying to develop new treatments for pediatric intractable diseases, such as, intestinal motility disorders (allied disorders of Hirschsprungʼs disease, liver failure and enzyme-deficient diseases, and severe congenital diaphragmatic hernia, using cell therapy and tissue engineering technology including SHED.

Journal

  • 福岡醫學雜誌

    福岡醫學雜誌 111 (3), 113-123, 2020-09-25

    Fukuoka Medical Association

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