書誌事項
- タイトル別名
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- Prognostic factors for progression of visual field deterioration in patients with primary open-angle glaucoma
- カイホウ グウカク リョクナイショウ カンジャ ニ オケル シヤ ショウガイ シンコウ インシ ノ ケントウ
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Purpose: To elucidate possible clinical factors affecting visual field (VF) deterioration in patients with primary open angle glaucoma (POAG).Patients and methods: 47 eyes of 29 POAG patients who were or were not receiving glaucoma edications were included. Each subject underwent VF tests 3 or more times using the Humphrey Field Analyzer 30-2 (HFA30-2). Based on their scores for three patterns of classification - (1) Advanced Glaucoma Intervention Study visual field defect score (AGIS score), (2) mean deviation slope (MD slope), (3) both AGIS score and MD slope - patients were divided into a progressive group and non-progressive group. Intraocular pressure (IOP) measurements at 14 time points (12, 15, 18, 21, 0, 6, 9, 12, 15, 18, 21, 0, 6 and 9 o’clock) were performed over a period of 48 hrs. IOP fluctuations were classified into 4 patterns (diurnal acrophase, nocturnal acrophase, flat and double acrophase). Several clinical factors between the two groups, including age, sex, central corneal thickness, visual acuity, refraction, the number of anti-glaucoma medication, mean IOP, maximum IOP, minimum IOP, IOP fluctuation and circadian IOP fluctuation patterns were compared.Results: Patient age and a nocturnal acrophase pattern were found to be significant factors related to the progression of VF deterioration. Patients in the progressive group were significantly younger than those in the non-progressive group in the MD slope classification (odds ratio = 0.913, P = 0.013). Nocturnal acrophase circadian patterns were more frequently observed in the progressive groups classified with AGIS score and both of AGIS score and MD slope.Conclusions: These findings suggest that age and nocturnal acrophase patterns are possible clinical factors related to the progression of VF deterioration in patients with POAG.
収録刊行物
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- 札幌医学雑誌 = The Sapporo Medical Journal
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札幌医学雑誌 = The Sapporo Medical Journal 86 (1-6), 33-43, 2017
札幌医科大学医学部
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詳細情報 詳細情報について
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- CRID
- 1390290699788694656
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- NII論文ID
- 120006488956
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- NII書誌ID
- AN00097280
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- NDL書誌ID
- 028997116
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- ISSN
- 0036472X
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
- IRDB
- NDL
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用可