エンドトキシン誘発播種性血管内凝固に対する糖尿病の影響

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  • エンドトキシン ユウハツ ハシュセイ ケッカンナイ ギョウコ ニ タイスル トウニョウビョウ ノ エイキョウ

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This paper is a study concerning diabetes that have a tendency for blood coagulation whether it was a risk of sudden death. We made a diabetes model mouse by intraperitoneal injection of streptozotocin (STZ), and we caused disseminated intravascular coagulation (DIC) by doing an intra-tailvenous injection of endotoxin (ET) to the mouse. After injection of STZ, a weight loss, decrease of intra-abdominal fat, polyphagy, polyposia are induced and they are the main symptoms of diabetes. Furthermore, with an ET injection to the mouse, it showed increase of weight such as the lung and the liver and extension of PT time with the blood clot formation, and that it was it in a blood coagulation tendency was confirmed by these symptoms. Then, the mouse showed a decrease of plasminogen activator activity in the lung. Therefore, fibrinolysis system was enhanced in the mouse, and it was suggested that a symptom of DIC turned worse under a state of diabetes.

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