Progressive Cytopenia Developing during Treatment of Cryptococcosis in a Patient with HIV Infection and Bone Marrow Cryptococcal Infection
-
- Katsura Mai
- AIDS Clinical Center of the National Center for Global Health and Medicine, Japan
-
- Okuhama Ayako
- AIDS Clinical Center of the National Center for Global Health and Medicine, Japan
-
- Koizumi Yoshiki
- AIDS Clinical Center of the National Center for Global Health and Medicine, Japan
-
- Ando Naokatsu
- AIDS Clinical Center of the National Center for Global Health and Medicine, Japan
-
- Yanagawa Yasuaki
- AIDS Clinical Center of the National Center for Global Health and Medicine, Japan
-
- Mizushima Daisuke
- AIDS Clinical Center of the National Center for Global Health and Medicine, Japan
-
- Aoki Takahiro
- AIDS Clinical Center of the National Center for Global Health and Medicine, Japan
-
- Tsukada Kunihisa
- AIDS Clinical Center of the National Center for Global Health and Medicine, Japan
-
- Teruya Katsuji
- AIDS Clinical Center of the National Center for Global Health and Medicine, Japan
-
- Kikuchi Yoshimi
- AIDS Clinical Center of the National Center for Global Health and Medicine, Japan
-
- Oka Shinichi
- AIDS Clinical Center of the National Center for Global Health and Medicine, Japan
-
- Watanabe Koji
- AIDS Clinical Center of the National Center for Global Health and Medicine, Japan
この論文をさがす
説明
<p>Cytopenia is a common complication in patients with human immunodeficiency virus (HIV) infection. Identifying the cause is demanding because of the wide range of possible diagnoses. We herein report an HIV-infected patient with disseminated cryptococcosis involving multiple organs including the blood, brain, lungs, and bone marrow, who developed progressive pancytopenia after initiation of anti-fungal treatment with liposomal amphotericin-B (L-AMB) and flucytosine (5FC). The pancytopenia persisted despite early 5FC discontinuation. A bone marrow biopsy revealed cryptococcal infiltration and the blood examination findings recovered quickly after resuming L-AMB. Thus, this HIV-infected patient's pathological findings and clinical course suggested that the primary cause of the pancytopenia was bone marrow cryptococcosis. </p>
収録刊行物
-
- Internal Medicine
-
Internal Medicine 61 (2), 257-261, 2022-01-15
一般社団法人 日本内科学会