Problems of PNI (prognostic nutritional index) in chronic liver disease

DOI
  • Suzuki Kazutomo
    Department of Gastrointestinal Medicine, Shuuwa General Hospital, Shuuwakai Medical Corporation, Saitama, Japan
  • Yamamoto Kouji
    Department of Clinical Laboratory, Shuuwa General Hospital, Shuuwakai Medical Corporation, Saitama, Japan
  • Goseki Narihide
    Department of Surgery, Shuuwa General Hospital, Shuuwakai Medical Corporation, Saitama, Japan

Bibliographic Information

Other Title
  • 慢性肝疾患における栄養指標としてのPNI（prognostic nutritional index）の問題点

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Description

<p>Aim: The prognostic nutritional index (PNI) is a prognostic predictor calculated from serum albumin (ALB) concentration and total peripheral lymphocyte count. This study investigated problems of the PNI associated with changes in the serum ALB measurement method in patients with chronic liver disease.</p><p>Subjects and Methods: Participants were 144 patients with chronic liver disease who visited our hospital from March 2018 to October 2018, and 364 healthy controls who visited our health checkup center from January 2017 to July 2018. The electrophoresis method and the modified bromocresol purple method were used to measure serum ALB concentration.</p><p>Results: Both serum ALB concentration and PNI value were significantly higher when the electrophoresis method was used than when the modified bromocresol purple method was used. Differences in serum ALB concentration and PNI value between the methods tended to increase with disease severity.</p><p>Conclusion: The PNI is a good comprehensive prognostic indicator, but it should be noted that the PNI value can vary depending on the method used to measure serum ALB concentration, and we should pay attention to the evaluation.</p>

Journal

  • Online Journal of JSPEN

    Online Journal of JSPEN 3 (3), 147-157, 2021

    Japanese Society for Parenteral and Enteral Nutrition Therapy

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