Development of Functional Food for Citrus and Application of Analysis for Mass Spectrometry Imaging

DOI Open Access
  • Yoshinouchi Shosei
    Cooperative Major in Advanced Health Science, Tokyo University of Agriculture and Technology
  • Tominari Tsukasa
    Department of Biotechnology and Life Science, Tokyo University of Agriculture and Technology
  • Hirata Michiko
    Department of Biotechnology and Life Science, Tokyo University of Agriculture and Technology
  • Miyaura Chisato
    Cooperative Major in Advanced Health Science, Tokyo University of Agriculture and Technology Department of Biotechnology and Life Science, Tokyo University of Agriculture and Technology
  • Shimma Shuichi
    Department of Biotechnology, Osaka University
  • Inada Masaki
    Cooperative Major in Advanced Health Science, Tokyo University of Agriculture and Technology Department of Biotechnology and Life Science, Tokyo University of Agriculture and Technology

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Other Title
  • 柑橘の機能性食品開発と質量分析イメージング解析への応用

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Abstract

<p>Human health is maintained by daily dietary food consumption to prevent lifestyle-related diseases in the super-aged society of Japan. Citrus-derived bioactive natural compounds including xanthophylls and polyphenols possess various beneficial effects such as antioxidative effects. Recently, the physiological activities of the foods have been elucidated that applied to functional foods development for various agricultural products. The high quality of qualitative and quantitative analysis for bioactive natural compounds contained functional foods has been increased the importance in the field of agricultural research communities. Liquid chromatography-mass spectrometry (LC-MS) is generally applied to the qualitative and quantitative analysis of many agricultural products containing functional food components. On the other hand, the spatial distribution of the bioactive natural compounds in the plant tissues is needed to develop a novel index for quality control of agricultural products. Matrix-assisted laser desorption/ionization (MALDI) mass spectrometry imaging (MSI) is an advanced technique for the analysis of the spatial distribution of components. MSI is to perform the direct mass spectrometry to the tissue surface, resulting in the visualization of target molecules showing a specific mass spectrum. In this study, we analyzed the distribution of natural compounds on the citrus tissue by MSI and further demonstrated that the evaluation of the functional evidence of the physiological activities using the mouse model. We suggest that the MSI technique is applied to the development of functional food through the spatial distribution of bioactive natural compounds on the tissues of agricultural products.</p>

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