A Case of Pulmonary Tuberculosis with Initial PZA Monoresistance Associated with Total Deletion of the <i>pncA </i>Gene

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  • KOBAYASHI Masahiro
    Department of Clinical Laboratory, National Hospital Organization Ibaraki-higashi National Hospital
  • MOTOKI Yuya
    Department of Clinical Laboratory, National Hospital Organization Ibaraki-higashi National Hospital
  • AONO Akio
    Department of Mycobacterium Reference and Research, Research Institute of Tuberculosis, Japan Anti-Tuberculosis Association
  • MITARAI Satoshi
    Department of Mycobacterium Reference and Research, Research Institute of Tuberculosis, Japan Anti-Tuberculosis Association
  • SAITO Takefumi
    Department of Respiratory Medicine, National Hospital Organization of Mycobacterium Reference National Hospital Organization Ibaraki-higashi National Hospital

Bibliographic Information

Other Title
  • <i>pncA </i>遺伝子の全欠損によりPyrazinamide単剤耐性を示した初回治療肺結核症の1例

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Description

<p>We report a newly diagnosed patient with pulmonary tuberculosis (TB) patient who showed initial monoresistance to pyrazinamide (PZA) associated with total deletion of the pncA gene. The patient was a 73- year-old man who was diagnosed as having pulmonary silicotuberculosis. He had no history of prior treatment for TB. In vitro major anti-tuberculosis drug susceptibility testing showed monoresistance to PZA. Further investigation at the Research Institute of Tuberculosis revealed that the species was Mycobacterium tuberculosis sensu stricto, that lacked pyrazinamidase activity. Further sequencing analysis revealed deletion of the entire pncA gene. To the best of our knowledge, this is the first reported case of PZA monoresistance associated with total pncA deletion.</p>

Journal

  • Kansenshogaku Zasshi

    Kansenshogaku Zasshi 95 (4), 343-347, 2021-07-20

    The Japanese Association for Infectious Diseases

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