Neutron Crystallography for the Understanding of Enzymatic Mechanisms

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  • 中性子結晶構造解析が解き明かす酵素反応
  • チュウセイシ ケッショウ コウゾウ カイセキ ガ トキアカス コウソ ハンノウ

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Abstract

<p>By using neutron crystallography, we determined the precise three-dimensional structure of a copper-containing nitrite reductase (CuNIR), a protein enzyme involved in the nitrogen cycle. Our data visualizes the positions of hydrogen atoms at the catalytic site and a hydroxide-bound state of CuNIR, which has been proposed by quantum chemical calculations. Other experimental findings including a tight hydrogen bond on a possible electron transfer pathway also supports previous results from theoretical chemistry.</p>

Journal

  • Butsuri

    Butsuri 77 (2), 83-87, 2022-02-05

    The Physical Society of Japan

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