Fermented rice bran supplementation ameliorates obesity via gut microbiota and metabolism modification in female mice

DOI Web Site 2 Citations 61 References
  • Tochitani Shiro
    Division of Health Science, Graduate School of Health Science, Suzuka University of Medical Science Department of Radiological Technology, Faculty of Health Science, Suzuka University of Medical Science Research Center for Child Mental Development, University of Fukui Department of Child Development, United Graduate School of Child Development, Osaka University Life Science Innovation Center, University of Fukui
  • Maehara Yoshiteru
    MAX PROBIO. Co. Ltd.
  • Kawase Takahiro
    Kyoto Institute of Nutrition & Pathology
  • Tsukahara Takamitsu
    Kyoto Institute of Nutrition & Pathology
  • Shimizu Ryoichi
    Faculty of Medical Sciences, University of Fukui
  • Watanabe Taizo
    MAX PROBIO. Co. Ltd.
  • Maehara Kazuo
    MAX PROBIO. Co. Ltd.
  • Asaoka Kenji
    MAX PROBIO. Co. Ltd.
  • Matsuzaki Hideo
    Research Center for Child Mental Development, University of Fukui Department of Child Development, United Graduate School of Child Development, Osaka University Life Science Innovation Center, University of Fukui

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<p>We investigated the effects of fermented rice bran (FRB) administration in two groups of C57BL/6J mice. The first group was fed with a high-fat diet, and the second group was fed with a high-fat diet supplemented with the FRB for 8 weeks. FRB supplementation suppressed the high-fat-induced weight gain and considerable alterations in the intestinal microbiota profile in the second group. Among 27 bacterial genera detected in the FRB, only Enterococcus, Lactobacillus, Bacteroides, Prevotella, and the unclassified family Peptostreptococcaceae were detected in mice feces. Their abundances were not particularly increased by FRB supplementation. The abundances of Enterococcus and the unclassified family Peptostreptococcaceae were even suppressed in the second group, suggesting that FRB supplementation didn’t cause an addition of beneficial microbiome but inhibit the proliferation of specific bacteria. Fecal succinic acid concentration was significantly decreased in the second group and highly correlated with the relative abundances of Turicibacter, Enterococcus, and the unclassified family Peptostreptococcaceae. A significant increase in fumaric acid and a decrease in xylitol, sorbitol, uracil, glutamic acid, and malic acid levels were observed in the peripheral blood of the second group. FRB supplementation counteracted the high-fat-induced obesity in mice by modulating the gut microbiota and the host metabolism.</p>

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