Advanced Diffusion MR Imaging for Multiple Sclerosis in the Brain and Spinal Cord
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- Hori Masaaki
- Department of Radiology, Toho University Omori Medical Center Department of Radiology, Juntendo University School of Medicine
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- Maekawa Tomoko
- Department of Radiology, Juntendo University School of Medicine
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- Kamiya Kouhei
- Department of Radiology, Toho University Omori Medical Center Department of Radiology, Juntendo University School of Medicine
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- Hagiwara Akifumi
- Department of Radiology, Juntendo University School of Medicine
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- Goto Masami
- Department of Radiological Technology, Faculty of Health Science, Juntendo University
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- Takemura Mariko Yoshida
- Department of Radiology, Toho University Omori Medical Center
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- Fujita Shohei
- Department of Radiology, Juntendo University School of Medicine
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- Andica Christina
- Department of Radiology, Juntendo University School of Medicine
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- Kamagata Koji
- Department of Radiology, Juntendo University School of Medicine
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- Cohen-Adad Julien
- NeuroPoly Lab, Polytechnique Montreal
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- Aoki Shigeki
- Department of Radiology, Juntendo University School of Medicine
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Abstract
<p>Diffusion tensor imaging (DTI) has been established its usefulness in evaluating normal-appearing white matter (NAWM) and other lesions that are difficult to evaluate with routine clinical MRI in the evaluation of the brain and spinal cord lesions in multiple sclerosis (MS), a demyelinating disease. With the recent advances in the software and hardware of MRI systems, increasingly complex and sophisticated MRI and analysis methods, such as q-space imaging, diffusional kurtosis imaging, neurite orientation dispersion and density imaging, white matter tract integrity, and multiple diffusion encoding, referred to as advanced diffusion MRI, have been proposed. These are capable of capturing in vivo microstructural changes in the brain and spinal cord in normal and pathological states in greater detail than DTI.</p><p>This paper reviews the current status of recent advanced diffusion MRI for assessing MS in vivo as part of an issue celebrating two decades of magnetic resonance in medical sciences (MRMS), an official journal of the Japanese Society of Magnetic Resonance in Medicine.</p>
Journal
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- Magnetic Resonance in Medical Sciences
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Magnetic Resonance in Medical Sciences 21 (1), 58-70, 2022
Japanese Society for Magnetic Resonance in Medicine
