Clinical Significance of Chromosomal Instability in Gastric Cancer

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  • 胃癌におけるChromosomal Instabilityの臨床的意義
  • イガン ニオケル Chromosomal Instability ノ リンショウテキ イギ

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Abstract

The purpose of this study was to evaluate clinical significance of chromosomal instability(CIN)in primary gastric cancer. In 90 sporadic gastric carcinomas, we measured numerical aberrations for chromosome 7, 11, 17 and 18 by fluorescence in situ hybridization(FISH)with genomic probes for the centromeres of chromosome. Hybridization signals were counted in 200 interphase nuclei. The modal copy number of each chromosome was determined. The fraction of cells with chromosome numbers that differed from the mode(Variant Fraction:VF)was calculated for each chromosome. The degree of CIN was defined according to the size of VF. The degree of CIN was associated significantly with increased tumor depth, lymphnode metastasis, lymphatic invasion and venous invasion. When the grade of CIN was defined as follows:CIN1;VF<20% of the cells, CIN2;20%≦VF<40% of the cells, CIN3;40% of the cells≦VF, CIN status significantly correlated with overall survival(chromosome 7:CIN1 vs. CIN3 p=0.0385, chromosome 17:CIN1 vs. CIN3 p=0.0798, chromosome 18:CIN1 vs. CIN2 p=0.0658, CIN1 vs. CIN3 p=0.00744).Analysis of CIN status may be clinically significant in evaluation of degree of malignancy in patient with gastric cancer.

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