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- 吉岡 俊彦
- 徳島大・院医歯薬・臨床薬理学 徳島大学病院・薬剤部
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- 合田 光寛
- 徳島大・院医歯薬・臨床薬理学 徳島大学病院・薬剤部
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- 神田 将哉
- 徳島大・院医歯薬・臨床薬理学 徳島大学病院・薬剤部
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- 吉田 愛美
- 徳島大・院医歯薬・臨床薬理学
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- 糸林 小友理
- 徳島大・院医歯薬・臨床薬理学
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- 杉本 祐悟
- 徳島大・院医歯薬・臨床薬理学
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- 石澤 有紀
- 徳島大・院医歯薬・薬理学
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- 八木 健太
- 徳島大学病院・総合臨床研究セ
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- 相澤 風花
- 徳島大学病院・薬剤部
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- 濱野 裕章
- 徳島大学病院・総合臨床研究セ
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- 岡田 直人
- 徳島大学病院・薬剤部
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- 座間味 義人
- 徳島大・院医歯薬・臨床薬理学 岡山大学病院・薬剤部
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- 石澤 啓介
- 徳島大・院医歯薬・臨床薬理学 徳島大学病院・薬剤部
書誌事項
- タイトル別名
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- Effects of sodium valproate on cisplatin-induced acute kidney injury
抄録
<p>OBJECTIVE: Cisplatin-induced acute kidney injury (AKI) is well known, and the nephrotoxicity of cisplatin restricts its clinical application. Currently, there are no drugs are recommended for the prevention of cisplatin-induced AKI. Forced hydration and diuresis may partially prevent nephrotoxicity of cisplatin, but it is still difficult to entirely prevent kidney injury. Thus, establishment of a new preventive method against cisplatin-induced AKI is required. Therefore, in this study, the purpose of this study was to clarify the efficacy of sodium valproate in cisplatin-induced AKI.</p><p>METHODS: In order to establish cisplatin‐induced AKI animal model, C57BL/6 mice were administered with either cisplatin (15 mg/kg, i.p.) or saline (control). The degree of renal damage was assessed by various renal function parameters and pathological evaluation. The effect of sodium valproate on cisplatin-induced cytotoxicity was evaluated using HK2 cells, MKN-1 cells and LLC cells.</p><p>RESULTS: Cisplatin treatment worsened various renal function parameters and tubular damage scores, which were significantly improved by co-treatment with sodium valproate. The decrease in cell viability of HK2 cells by cisplatin was significantly improved by co-treatment with sodium valproate. On the other hand, sodium valproate had no adverse effect on the reduction of cell viability of various cancer cells by cisplatin.</p><p>CONCLUSIONS: The results of this study indicated that sodium valproate could act as a potential preventive drug for cisplatin-induced AKI.</p><p></p>
収録刊行物
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- 日本薬理学会年会要旨集
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日本薬理学会年会要旨集 95 (0), 1-SS-48-, 2022
公益社団法人 日本薬理学会
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キーワード
詳細情報 詳細情報について
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- CRID
- 1390291767676156800
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- ISSN
- 24354953
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
- Crossref
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- 抄録ライセンスフラグ
- 使用不可