書誌事項
- タイトル別名
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- ケッセイ レクチン ト メタロプロテアーゼ ト ノ ソウゴ サヨウ ノ モツ セイリテキ ・ ビョウリテキ イギ
- Functional interaction of a serum lectin with metalloproteases
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type:Article
Mannan-binding protein (MBP) is a Ca^<2+>-dependent lectin known as a host defense factor involved in innate immunity, and recognizes mannose, fucose, and N-acetylglucosamine residues. The biological responses of MBP to exogenous ligands have been studied extensively, however, little is known about its role to endogenous ligands. We have identified meprins, matrix metalloproteases, as novel endogenous MBP ligands in the renal proximal tubules of mouse. We found that the binding of MBP to meprins resulted in significant decreases in the proteolytic and matrix-degrading activities, indicating that MBP is an important regulator for the local modulation of meprin proteolytic activity. On the other hand, focusing on the pathogenic role of the interaction of MBP with meprins, we clarified that, in an acute renal failure caused by ischemia/reperfusion injury, the binding of MBP with meprins triggers the complement activation on the renal proximal tubules through the lectin pathway.
identifier:http://repository.seikei.ac.jp/dspace/handle/10928/299
収録刊行物
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- 成蹊大学理工学研究報告 = The journal of the Faculty of Science and Technology, Seikei University
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成蹊大学理工学研究報告 = The journal of the Faculty of Science and Technology, Seikei University 49 (2), 33-44, 2012-12-01
成蹊大学理工学部
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詳細情報 詳細情報について
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- CRID
- 1390291767726492288
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- NII論文ID
- 120005271065
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- NII書誌ID
- AA1203510X
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- ISSN
- 18802265
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- NDL書誌ID
- 024200739
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
- IRDB
- NDL
- CiNii Articles