Study of serum staphylococcal enterotoxin-specific IgE in patients with sinusitis

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  • Nakamura Chihiro
    Department of Otorhinolaryngology, Hirosaki University Graduate School of Medicine Department of Otorhinolaryngology, Hachinohe City Hospital
  • Takahata Junko
    Department of Otorhinolaryngology, Hirosaki University Graduate School of Medicine
  • Shimizume Nami
    Department of Otorhinolaryngology, Hirosaki University Graduate School of Medicine
  • Kudo Reiko
    Department of Otorhinolaryngology, Hirosaki University Graduate School of Medicine
  • Mitsuhashi Yuri
    Department of Otorhinolaryngology, Tsugaru General Hospital
  • Nomura Ayami
    Department of Otorhinolaryngology, Odate Municipal General Hospital
  • Matsubara Atsushi
    Department of Otorhinolaryngology, Hirosaki University Graduate School of Medicine

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Other Title
  • 副鼻腔炎症例における血清黄色ブドウ球菌エンテロトキシン特異的IgEの検討

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Abstract

<p>It has been suggested that staphylococcal enterotoxin (SE) may be involved in type 2 inflammation such as eosinophilic chronic rhinosinusitis via innate lymphoid cells. In this study, the clinical features of a total of 78 patients with sinusitis who visited our department between March 2018 and January 2021 and underwent serum SE-specific IgE testing, were investigated. The present study investigated the serum SE-specific IgE positive rate, and compared peripheral blood eosinophil count, total IgE, ImmunoCAP of various antigens, and JESREC score in the SE-specific IgE positive and the SE-specific IgE negative groups.</p><p>As a result, serum SE-specific IgE showed a positive rate of 14.1% (11/78 cases) overall, of which the SE-specific IgE positive rate of eosinophilic chronic rhinosinusitis was 26.8% (9/41 cases), which was significantly higher than the SE-specific IgE positive rate of non-eosinophilic chronic rhinosinusitis of 5.4% (2/37 cases). In the SE-specific IgE positive group, JESREC score was significantly higher, and the peripheral blood eosinophil count and total IgE also tended to be higher. Furthermore, the SE-specific IgE positive group tended to have higher complications of eosinophilic otitis media.</p><p>These results are consistent with the idea that serum SE-specific IgE reflects the pathophysiology of type 2 inflammation in eosinophilic chronic rhinosinusitis and is involved in its pathology.</p>

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