Impact of Minocycline Ointment for Periodontal Treatment of Oral Bacteria
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- Nakao Ryoma
- Department of Bacteriology I, National Institute of Infectious Diseases, Japan
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- Takigawa Satoko
- Department of Periodontology, Nihon University School of Dentistry, Japan
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- Sugano Naoyuki
- Department of Periodontology, Nihon University School of Dentistry, Japan
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- Koshi Ryosuke
- Department of Periodontology, Nihon University School of Dentistry, Japan
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- Ito Koichi
- Department of Periodontology, Nihon University School of Dentistry, Japan
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- Watanabe Haruo
- Department of Bacteriology I, National Institute of Infectious Diseases, Japan
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- Senpuku Hidenobu
- Department of Bacteriology I, National Institute of Infectious Diseases, Japan
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Description
<p>Topical tetracyclines, such as minocycline ointment, are frequently used for the treatment of periodontal infection. We investigated the influence of minocycline ointment use on oral bacteria, using supragingival plaque samples from adults who had not taken any antibiotics for 6 months. Initially we investigated the effect of topical minocycline administration on the emergence of tetracycline-resistant oral bacteria in four healthy adults. The isolation frequency of tetracycline-resistant oral bacteria to total viable bacteria increased substantially on day 6 after treatment, although it returned to baseline on day 25. Subsequently we investigated the isolation frequency of tetracycline-resistant oral streptococci (TOS) as a representative oral bacterium, using samples from 41 subjects with periodontal diseases. The percentage of TOS (of the total oral streptococci) increased significantly (from 11.9±15.6% to 34.2±24.0%) after minocycline treatment. Various TOS species were identified; S. mitis, S. salivarius, S. sanguinis, and S. oralis were frequently isolated. PCR and Southern blotting allowed us to identify tetM on the Tn916-like elements as the gene responsible for tetracycline-resistance. These findings suggest that the potential risk of the spread of similar genetic elements through bacteria in the oral cavity should be considered.<tt> </tt></p>
Journal
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- Japanese Journal of Infectious Diseases
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Japanese Journal of Infectious Diseases 64 (2), 156-160, 2011-03-31
National Institute of Infectious Diseases, Japanese Journal of Infectious Diseases Editorial Committee
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Keywords
Details 詳細情報について
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- CRID
- 1390291767791407616
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- NII Article ID
- 40018775777
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- NII Book ID
- AA1132885X
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- ISSN
- 18842836
- 13446304
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- NDL BIB ID
- 11054231
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- PubMed
- 21519133
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL Search
- Crossref
- CiNii Articles
- OpenAIRE
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- Abstract License Flag
- Disallowed