Molecular epidemiology and antimicrobial resistance determinants of multidrug-resistant Acinetobacter baumannii in five proximal hospitals in Taiwan

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  • Lin Ming-Feng
    Department of Medicine, Chutung Hospital, Department of Health, Taiwan, Republic of China Institute of Molecular and Cellular Biology, National Tsing Hua University, Taiwan, Republic of China
  • Chang Kai-Chih
    Department of Laboratory Medicine and Biotechnology, Tzu Chi University, Taiwan, Republic of China
  • Lan Chung-Yu
    Institute of Molecular and Cellular Biology, National Tsing Hua University, Taiwan, Republic of China
  • Chou Juiling
    Department of Biotechnology, Yuanpei University, Taiwan, Republic of China
  • Kuo Jai-Wei
    Department of Biotechnology, Yuanpei University, Taiwan, Republic of China
  • Chang Chih-Kai
    Department of Medical Laboratory Science and Biotechnology, Yuanpei University, Taiwan, Republic of China
  • Liou Ming-Li
    Department of Medical Laboratory Science and Biotechnology, Yuanpei University, Taiwan, Republic of China

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  • Molecular Epidemiology and Antimicrobial Resistance Determinants of Multidrug-Resistant <i>Acinetobacter baumannii</i> in Five Proximal Hospitals in Taiwan

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<p>We investigated the molecular epidemiology, antibiotic susceptibility, and antimicrobial resistant gene determinants of 23 multidrug-resistant (MDR) Acinetobacter baumannii samples that were collected from 5 proximal hospitals in Taiwan during April and May 2009. Major antibiotic resistance varied from 82.6 to 100%. Fivw pulsotypes were observed to spread clonally among the 5 hospitals. PCR screening revealed high distributions of intI1 (91%), blaOXA-23 (57%), blaampC (100%), adeB (100%), adeJ (100%), and abeM (100%) genes, which were prevalent in the MDR A. baumannii isolates. Resistance gene expression was examined by reverse transcription-PCR, and showed that increased ampC expression was associated with ceftazidime resistance, but expression of adeB, adeJ, or abeM did not guarantee antimicrobial resistance phenotypes. In addition, imipenem resistance in some A. baumannii strains may be mainly modulated by genes other than blaOXA-51-like. This is the first direct evidence indicating local spread of MDR A. baumannii in Taiwan. The resistance gene determinants are widely distributed in clonal and nonclonal-related isolates.<tt> </tt></p>

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