HIV-negative plasmablastic lymphoma sustaining long-term response after autologous peripheral blood stem cell transplantation

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  • KITAGAWA Tomoya
    Department of Hematology, Kokura Memorial Hospital Department of Hematology, Kansai Electric Power Hospital
  • ONAKA Takashi
    Department of Hematology, Kansai Electric Power Hospital
  • YONEZAWA Akihito
    Department of Hematology, Kansai Electric Power Hospital

Bibliographic Information

Other Title
  • 自家末梢血幹細胞移植併用大量化学療法後に長期寛解を維持しているHIV陰性形質芽球性リンパ腫
  • ジカ マッショウケツ カンサイボウ イショク ヘイヨウ タイリョウ カガク リョウホウ ゴ ニ チョウキカンカイ オ イジ シテ イル HIV インセイ ケイシツ ガキュウセイ リンパシュ

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Abstract

<p>The patient is a 34-year-old HIV antibody-negative female with normal immunocompetence. The patient was referred to the hospital of the current study due to diarrhea and abdominal pain, which developed in May 2014. On conducting computed tomography (CT), remarkable wall thickening was noted in the terminal ilium over the ascending colon, suggesting a malignant tumor. However, making a definite diagnosis by lower gastrointestinal endoscopic biopsy and left hemicolectomy was not possible. The dense proliferation of plasma cell-like cells and plasmablasts was noted; CD20, CD19, CD79a, CD3, CD4, and Epstein-Barr virus-encoded miRNAs (EBER) were negative and CD138 was positive on immunostaining. Based on the aforementioned data, the patient was diagnosed with plasmablastic lymphoma (PBL). High-dose chemotherapy combined with autologous peripheral blood stem cell transplantation (PBSCT) was performed in the first remission period after the completion of four cycles of hyper CVAD/MTX-AraC alternating therapy. Remission was confirmed by FDG-PET/CT 3 months after autologous PBSCT. No signs of recurrence have been observed in 6 years after the transplantation. Although no standard treatment for PBL has been established, autologous peripheral blood stem cell transplantation combined with high-dose chemotherapy during the first remission period may be a beneficial treatment option.</p>

Journal

  • Rinsho Ketsueki

    Rinsho Ketsueki 63 (3), 201-205, 2022

    The Japanese Society of Hematology

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