T serotype and antimicrobial susceptibility of <i>Streptococcus pyogenes</i> isolated in the pediatric department of a regional hospital during a one-year period from May 2018: Comparison with results of five previous investigations

DOI Web Site

Bibliographic Information

Other Title
  • 2018年5月からの1年間に当院小児科において分離された<i>Streptococcus pyogenes</i>のT血清型と抗菌薬感受性―過去5回の調査成績との比較―
  • 2018年5月からの1年間に当院小児科において分離されたStreptococcus pyogenesのT血清型と抗菌薬感受性 : 過去5回の調査成績との比較
  • 2018ネン 5ガツ カラ ノ 1ネンカン ニ トウ イン ショウニカ ニ オイテ ブンリ サレタ Streptococcus pyogenes ノ T ケッセイガタ ト コウキンヤク カンジュセイ : カコ 5カイ ノ チョウサ セイセキ ト ノ ヒカク

Search this article

Abstract

<p>During a one-year period between May 2018 and April 2019, 175 Streptococcus pyogenes strains were isolated from 175 patients (age range, 1 month–14 years; median age, 4 years 10 months) in the pediatric department of our hospital. The T serotypes of the isolated S. pyogenes strains, the MICs of 13 antimicrobials (benzylpenicillin, cefditoren, cefotaxime, ceftriaxone, cefepime, meropenem, erythromycin, clarithromycin, azithromycin, clindamycin, tosufloxacin, levofloxacin, and vancomycin), and induction of clindamycin resistance were investigated and compared with those obtained in our five previous investigations (1996, 2001, 2003, 2006, and 2013). The T serotypes of the isolates were as follows: type 1, 64%; type 12, 18.3%; type B3264, 9.1%; and type 4, 2.3%. The isolation rate of type 1 was markedly higher and that of type 12 was lower than those in all five previous investigations. Resistance to erythromycin, clarithromycin, azithromycin, clindamycin, and levofloxacin was seen in 41.7%, 42.3%, 42.3%, 11.4%, and 1.1% of strains, respectively, and two (1.8%) isolates showed inducible clindamycin resistance. None of the strains were resistant to β-lactam antimicrobials or vancomycin. There was a trend of increasing erythromycin resistance rate (1996, 8.6%; 2001, 13.6%; 2003, 20.0%; 2006, 19.6%; 2013, 58.1%; 2018, 41.7%). Approximately half of the strains were found to be macrolide-resistant in more recent investigations. None of the 1,871 isolates, including those from the previous five investigations, included β-lactam antimicrobial- or vancomycin-resistant strains.</p>

Journal

Keywords

Details 詳細情報について

Report a problem

Back to top