Pharmacists’ view of sensory and immune hypersensitivity in cerebrospinal fluid hypovolemia: a review of four core symptoms in 221 cases

<p>Cerebrospinal fluid (CSF) hypovolemia, or CSF leak is an acquired chronic disease in which a variety of systemic physical conditions occur following a traumatic onset event factor, such as traffic accidents, sports injuries, falls, domestic violence, medical procedures such as lumbar anesthesia, or childbirth, but the onset event factor is often unknown. The incidence of the disease in blood relatives is also scattered. CSF hypovolemia is said to be caused by leakage (excessive absorption) of CSF at the spinal nerve roots, but its pathogenesis remains unclear. The clinical picture that characterizes CSF hypovolemia is a multilayered pattern of four core symptoms (autonomic symptoms, affective and cognitive symptoms, pain and sensory sensitivity, and immune sensitivity) that occur in individual patients. Many patients show thirst and dehydration tendency. There is a gender difference in CSF hypovolemia, with women having a higher frequency and severity of each symptom than men. Environmental stresses include physical sensory stress, chemical sensory stress, immune and coagulation system stress, psychosocial stress, and internal environmental stress. CSF hypovolemia has a state of hypersensitivity of the stress sensory input system or intolerance of the stress response output system to environmental stress. It is characterized by a pronounced deterioration in physical condition, especially with changes in weather conditions. The similarities between CSF hypovolemia and myalgic encephalomyelitis/chronic fatigue syndrome, cervical cancer vaccine adverse reactions, and chronic sequelae of COVID-19 have been noted, and their pathology can be described as manifestation of hypothalamic stress intolerant and exhaustive syndrome or periventricular organ dysregulation syndrome.</p>