Involvement of trace metals in the reduction of disulfide bonds by glutathione

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  • グルタチオンによるジスルフィド結合の還元反応に対する微量金属の関与

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The effect of trace metal elements on the reduction of oxidized proteins containing cystine in their structures was investigated using glutathione (GSH) as a reducing agent and zinc finger protein as a substrate for the reduction reaction. The effect of metal ions on the reduction of GAGA zinc finger was investigated. As a result, it was found that the metal ion is significantly involved in the reactivity of the disulfide reduction by coordination binding to the reaction intermediate, the GSH-mono adduct.

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