書誌事項
- タイトル別名
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- Comparisons between Duotrava<sup>®</sup> Combination Ophthalmic Drops and a Generic Equivalent:
- Pharmaceutical Assessment and Analysis of Dropper Bottle Usability and Nozzle color Visibility
- －点眼容器の使用性および点眼ノズルの色彩の違いによる視認性に関する検討－
- 公開日
- 2021-06-10
- DOI
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- 10.5649/jjphcs.47.326
- 公開者
- 一般社団法人日本医療薬学会
この論文をさがす
説明
<p>Duotrava® ophthalmic drops (hereafter referred to as “brand-name drug”), a fixed-dose combination drug used for the treatment of glaucoma, has one commercially available generic equivalent at February, 2021. In the present study, we compared the brand-name drug and its generic equivalent with respect to viscosity, pH, and osmolality. We measured the mass of a single drop, squeezing force for dispensing a single drop, and number of drops per bottle. We also surveyed healthy individuals on product usability. In addition, we utilized a colorimeter to measure differences in bottle nozzle color and assessed nozzle color visibility among healthy individuals. Results showed that physical properties were nearly identical between the brand-name drug and its generic equivalent. However, bottle usability was significantly higher for the generic equivalent than for the brand-name drug. For both preparations, bottles containing a larger number of drops required greater squeezing force. However, subjects preferred bottles that discharged medication at a consistent squeezing force regardless of the number of drops remaining. The nozzle color assessment revealed that nozzles with high color contrast ratios were more visible than conventional white nozzles, and we observed a correlation between the nozzle color selection rate and contrast ratio. These results suggest the need for comprehensively considering patient usability, especially with regard to the design of the dispensing container, when developing ophthalmic drops.</p>
収録刊行物
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- 医療薬学
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医療薬学 47 (6), 326-334, 2021-06-10
一般社団法人日本医療薬学会
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詳細情報 詳細情報について
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- CRID
- 1390292350996223360
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- ISSN
- 18821499
- 1346342X
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
- Crossref
- OpenAIRE
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- 抄録ライセンスフラグ
- 使用不可
