A case of anti-leucine-rich glioma-inactivated 1 antibody-associated autoimmune encephalitis with faciobrachial dystonic seizure

DOI
  • Higashimori Yusei
    Department of Neurology, University of Occupational Environmental Health, Japan
  • Hashimoto Tomoyo
    Department of Neurology, University of Occupational Environmental Health, Japan
  • Nagasaka Shohei
    Department of Neurosurgery, University of Occupational Environmental Health, Japan
  • Yamamoto Junko
    Department of Neurosurgery, University of Occupational Environmental Health, Japan
  • Akamatsu Naoki
    Brain and Neurological function center, Fukuoka Sanno Hospital Department of Neurology, International University of Health and Welare
  • Okada Kazumasa
    Department of Neurology, University of Occupational Environmental Health, Japan
  • Adachi Hiroaki
    Department of Neurology, University of Occupational Environmental Health, Japan

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Other Title
  • 抗LGI1抗体陽性自己免疫性脳炎の1例

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<p>We report a 79-year-old man with leucine-rich glioma-inactivated 1 (LGI1) antibody-associated autoimmune encephalitis following faciobrachial dystonic seizure (FBDS). 4 months before his admission, he developed partial seizures manifesting very brief and frequent dystonia in his right side of face and right hand. In addition, he started to wake suddenly from sleep with a loud scream and experience hallucination. On admission, he showed loss of consciousness and hyponatremia, and developed generalized convulsive status epilepticus. Brain MRI demonstrated high T2/FLAIR signal changes in the bilateral amygdala and chronic subdural hematoma. After removal of subdural hematoma and anti-epileptic drugs therapy, however seizures were not controlled. Treatment with high dose intravenous methylprednisolone and oral prednisolone was highly effective against his symptoms. Our findings collectively suggested that detection of FBDS is important for early diagnosis of anti-LGI1 antibody-associated autoimmune encephalitis and appropriate treatment selection.</p>

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