Drug design for induction of antigen-specific immune tolerance

DOI Web Site 38 References Open Access
  • Liu Yiwei
    Department of Applied Chemistry, Faculty of Engineering, Kyushu University
  • Mori Takeshi
    Department of Applied Chemistry, Faculty of Engineering, Kyushu University

Bibliographic Information

Other Title
  • 抗原特異的な免疫寛容を誘導する医薬品の設計

Search this article

Description

Allergies and autoimmune diseases caused by the breakdown of immune tolerance to harmless foreign antigens and self-antigens have been attracting attention in recent years as the number of patients increases. The development of antigen-specific immunotherapy for complete cure of allergies and autoimmune diseases, which artificially induces immune tolerance to antigens, has been studied. Immune tolerance therapy requires efficient and specific delivery of antigens to target immune cells, followed by induction of immune cells into a tolerogenic phenotype or anergy. In this process, drugs are required to perform three functions：evasion of the immune response to the antigen, targeting of the immune cells, and regulation of the immune cells. In this review, strategies and drug design for inducing antigen-specific immune tolerance are outlined, examples of recent research are presented, and future prospects are discussed.

Journal

  • Drug Delivery System

    Drug Delivery System 37 (2), 142-148, 2022-03-25

    THE JAPAN SOCIETY OF DRUG DELIVERY SYSTEM

References(38)*help

See more

Keywords

Details 詳細情報について

Report a problem

Back to top